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- STAT1 Antibodies
Invitrogen
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
View all (83) STAT1 antibodies
Cite STAT1 Polyclonal Antibody
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STAT1 Antibody (PA5-81911)
Relative expression in western blot: Antibody specificity was demonstrated by detection of known differential basal expression of the target across tissue/cell models. Expression of STAT1 was observed specifically in SK-MEL-30 cells and in HEK293 cells using anti-STAT1 Polyclonal Antibody (Product #PA5-81911) in western blot. The relative expression levels of STAT1 within each cell line is shown using RNA-S... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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Product Details
PA5-81911
Applications
Tested Dilution
Publications
Western Blot(WB)
0.04-0.4 µg/mL
-
Immunohistochemistry (IHC)
1:500-1:1,000
-
Immunocytochemistry(ICC/IF)
0.25-2 µg/mL
-
Product Specifications
Species Reactivity
Human,Mouse,Rat
Host/Isotype
Rabbit/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human STAT1
Conjugate
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Purification
Anitgen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2789072
Product Specific Information
Immunogen sequence: LLRFSESSRE GAITFTWVER SQNGGEPDFH AVEPYTKKEL SAVTFPDIIR NYKVMAAENI PENPLKYLYP NIDKDHAFGK YYSRPKEAPE PMELDGPKGT GYIKTELISV SEVHPSRLQT TDNLLPMSPE EFDEVSRIVG SVE
Target Information
STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6. STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2. STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. Among the seven STATs types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases:DKFZp686B04100; OTTHUMP00000165046; OTTHUMP00000205845; signal transducer and activator of transcription 1; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; Signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription-1; STAT; STAT 1; STAT-1; stat1 alpha; Transcription factor ISGF-3 components p91/p84
Gene Aliases:2010005J02Rik; AA408197; CANDF7; DD6G4-4; IMD31A; IMD31B; IMD31C; ISGF-3; STAT1; STAT91
UniProt ID:(Human) P42224
Entrez Gene ID:(Human) 6772, (Mouse) 20846, (Rat) 25124
Molecular Function: 
DNA-binding transcription factor
Function(s)
negative regulation of transcription from RNA polymerase II promoternegative regulation of endothelial cell proliferationpositive regulation of mesenchymal cell proliferationnegative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesistranscription, DNA-templatedapoptotic processJAK-STAT cascadeblood circulationmacrophage derived foam cell differentiationnegative regulation of angiogenesistumor necrosis factor-mediated signaling pathwayresponse to cytokineresponse to interferon-betacellular response to interferon-betaregulation of apoptotic processnegative regulation of I-kappaB kinase/NF-kappaB signalingresponse to peptide hormoneendothelial cell migrationpositive regulation of transcription, DNA-templatedpositive regulation of transcription from RNA polymerase II promoternegative regulation by virus of viral protein levels in host cellpositive regulation of smooth muscle cell proliferationresponse to cAMPdefense response to virusinterferon-gamma-mediated signaling pathwayregulation of interferon-gamma-mediated signaling pathwaytype I interferon signaling pathwayregulation of type I interferon-mediated signaling pathwayrenal tubule developmentcellular response to organic cyclic compoundmetanephric mesenchymal cell proliferation involved in metanephros developmentmetanephric mesenchymal cell differentiationnegative regulation of metanephric nephron tubule epithelial cell differentiationcell-cell adhesionregulation of transcription, DNA-templatedtranscription from RNA polymerase II promoteractivation of cysteine-type endopeptidase activity involved in apoptotic processsignal transductionresponse to nutrientpositive regulation of cell proliferationresponse to mechanical stimulusresponse to bacteriumcytokine-mediated signaling pathwaylipopolysaccharide-mediated signaling pathwayresponse to lipopolysaccharidecellular response to insulin stimulusnegative regulation of macrophage fusionresponse to drugresponse to exogenous dsRNAcellular response to lipopolysaccharideregulation of transcription from RNA polymerase II promoterresponse to organic cyclic compoundresponse to hydrogen peroxide
Process(es)
RNA polymerase II core promoter proximal region sequence-specific DNA bindingRNA polymerase II core promoter sequence-specific DNA bindingtranscription factor activity, RNA polymerase II core promoter sequence-specificdouble-stranded DNA bindingtranscription factor activity, sequence-specific DNA bindingsignal transducer activitytumor necrosis factor receptor bindingprotein bindingenzyme bindingnuclear hormone receptor bindingidentical protein bindingprotein hom*odimerization activitycadherin binding involved in cell-cell adhesionDNA bindingCCR5 chemokine receptor bindingsequence-specific DNA bindingprotein phosphatase 2A binding
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